Avoid the burden of pumps and catheters with EXPAREL

Only EXPAREL provides long-lasting pain control in a single dose.

EXPAREL avoids the common problems associated with pumps and catheters1-4:

  • Migration1
  • Unpredictability/malfunction2-4
  • Patient compliance2
  • Leakage2,3
  • Infection4

Why risk toxicity with pumps and catheters?5

Risk Toxicity Graph

*Minimum local anesthetic threshold for CNS toxicity is 2000 ng/ml.7

Data from a single-center cumulative dose toxicity study characterizing serum bupivacaine concentrations over 72 hours in patients undergoing a total knee arthroplasty. Patients in the EXPAREL arm received EXPAREL 266 mg (20 mL) plus 30 mL of bupivacaine 0.5% as a periarticular injection (PAI). Patients in the continuous femoral nerve block arm received a bolus of 20 mL of bupivacaine 0.5% followed by 8 mL/h bupivacaine 0.5% for 48 hours and a PAI of 30 mL of bupivacaine 0.5% during surgery.6

CNS, central nervous system.

ASP, average sales price; CMS, Centers for Medicare and Medicaid Services.

Compare the cost


133 mg (10 mL)=$227.63

266 mg (20 mL)=$376.12

Continuous catheter

Average of $433.82 per patient

for device alone8

In the face of shortages,

EXPAREL requires significantly fewer local anesthetic resources than continuous catheters


One EXPAREL 266 mg (20 ml) single-use vial may require only one vial of bupivacaine


Less than one vial of bupivacaine when one EXPAREL 133 mg (10 ml) single-use vial is used in an interscalene brachial plexus nerve


Continuous catheters require up to 10 to 15 vials of bupivacaine‡§

EXPAREL delivers long-lasting pain control in a patient-friendly modality

  • No external devices attached to patients at discharge
  • No extra burden for patient to remove the catheter
  • No need for patient involvement once home
  • No unplanned phone calls related to patient compliance