Cost and Value

EXPAREL is available in 133 mg (10 mL) dose for $227.63 and 266 mg (20 mL) dose for $376.12. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids,* better pain control, and shorter LOS. These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Total Joint Arthroplasty: ASC in New Jersey

Study Methods

  • 51 consecutive TJA procedures performed with the use of EXPAREL by 3 fellowship-trained adult reconstruction surgeons
    • Procedures included THA, TKA, and UKA
  • Retrospective review of outpatient medical records and preoperative and postsurgical clinical charts

Safety Outcomes

  • All adverse events were minor and treated within the ASC without the need for overnight observation or hospitalization

Clinical and Economic Outcomes

In patients who received EXPAREL for analgesia

  • 84%

    of patients surveyed (n=19) reported pain level as expected and well controlled

  • 0%

    of patients required
    an ED visit for uncontrolled pain and postsurgical transfusion

  • 0%

    of patients experienced
    a reported adverse
    event that required
    prolonged care or
    hospitalization

  • 98%

    of patients
    were discharged
    to home

    • 1 THA patient elected to go to a rehabilitation facility prior to surgery

  • 80%

    of patients
    surveyed (n=19)
    would recommend
    the ASC to friends
    and family

 

TJA (N=51)

  • Preoperative regimen
    • 1 dose each of celecoxib, oxycodone hydrochloride extended release, and gabapentin
  • Perioperative regimen
    • 1 dose of intravenous acetaminophen and 2 doses of intravenous dexamethasone
  • Intraoperative regimen*
    • Periarticular injection of EXPAREL, epinephrine, morphine, methylprednisolone, and cefazolin in 20 mL of normal saline
  • Postsurgical regimen
    • Celecoxib, oxycodone hydrochloride extended release for 7 days, and oxycodone for breakthrough pain

THA (n=22)

  • Average surgical time was 132 minutes and total LOS was 6.3 hours
  • Received a lumbar epidural catheter in preoperative holding and propofol sedation intraoperatively

TKA (n=15)

  • Average surgical time was 130 minutes and total LOS was 7.1 hours
  • Received a single-dose femoral nerve block, a single-dose tibial nerve block, and an adductor canal catheter block in preoperative holding

UKA (n=14)

  • Average surgical time was 130 minutes and total LOS was 6.2 hours
  • Received a single-dose femoral nerve block, a single-dose tibial nerve block, and an adductor canal catheter block in preoperative holding

*The use of EXPAREL in combination with epinephrine is not part of the approved label.

TJA, total joint arthroplasty; TKA, total knee arthroplasty; UKA, unicondylar knee arthroplasty.

ASP, average sales price; CMS, Centers for Medicare and Medicaid Services.

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