Cost and Value

EXPAREL is available in 133 mg (10 mL) dose for $227.63 and 266 mg (20 mL) dose for $376.12. The 133 mg (10 mL) and 266 mg (20 mL) doses of EXPAREL are available in cartons of 4 and 10 vials. For more information please visit How to order EXPAREL.

Information below helps review the value of EXPAREL in a multimodal pain management protocol that can lead to fewer opioids,* better pain control, and shorter LOS. These, in turn, can lead to fewer patient complications and reduced hospital costs per patient.

Shoulder Arthroplasty: Hospital in Florida

Study Methods

  • 55 patients undergoing SA who received a standardized multimodal pain management approach alone (n=24) or a standardized multimodal pain management approach with EXPAREL and dexamethasone (n=31)
  • Retrospective cohort analysis

Clinical and Economic Outcomes

Patients who received EXPAREL and dexamethasone for analgesia had

  • Significantly less pain

    on POD 1

  • 51%

    less cumulative
    opioid use
    for all PODs

  • 50%

    reduction in LOS


SA (N=55)

  • Preoperative
    • Single-injection interscalene block with 1000 mg of intravenous acetaminophen, 600 mg of oral gabapentin, 10 mg of oral oxycodone, and 200 mg of oral celecoxib
  • Postsurgical
    • Intravenous ketorolac and acetaminophen with oral gabapentin for 24 hours after surgery
    • 5 mg and 10 mg of oxycodone for mild to moderate pain and 0.5 mg, 1 mg, and 2 mg of intravenous hydromorphone for moderate to severe pain


  • Intraoperative
    • Intravenous administration of 8 to 10 mg of dexamethasone and injection of 50 mL admixture of saline, 0.25% bupivacaine HCl with epinephrine, and EXPAREL. 20 mL of EXPAREL was diluted with 20 mL of saline and 10 mL of 0.25% bupivacaine HCl with epinephrine

*The clinical benefit of the decrease in opioid consumption was not demonstrated in the clinical trials.

The use of EXPAREL in combination with epinephrine is not part of the approved label.

POD, postoperative day; SA, shoulder arthroplasty; LOS, length of stay.