EXPAREL Provides Pain Relief When It Matters Most
EXPAREL in Obstetrics/Gynecologic Surgery
Clinical Efficacy
Manage Pain & Minimize Opioids After C-section
EXPAREL TAP block vs bupivacaine TAP block in C-section study1
52% Fewer Opioids
overall opioid consumption (P<0.0117) at 72 hours
Comparable Pain Control
overall opioid consumption through 72 hours
C-section, cesarean section; TAP, transversus abdominis plane.
Clinical & Economic Outcomes
EXPAREL is a cost-effective option for postsurgical pain management both in the hospital and in outpatient settings
Gynecologic Oncology Robotic-Assisted Hysterectomy2
Medical center in Minnesota
- Significantly less pain (P=0.05) over first 24 hours after infiltration
- 16.2 hours shorter LOS
- 63% fewer occurrences of nausea or vomiting
Cesarean Section3
Medical center in Texas
- Significantly better pain control (P<0.001)
- 47% reduction in postsurgical opioid consumption through 3 days*
- 1 day shorter LOS
- 15% reduction in PACU discharge readiness time (25 minutes)
- 39% reduction in time to ambulation
*The clinical benefit of the decrease in opioid consumption was not demonstrated in the clinical trials
Multimodal Protocols & Results
Multimodal approaches with or without ERAS protocols have demonstrated benefits in obstetric and gynecologic procedures
Reduced opioid use and risk of ORAEs4-8
Fewer postsurgical complications6
Higher patient satisfaction5,6
Earlier mobility4,9
Shorter hospital LOS6,7
Reduced healthcare costs7
Societies Recommend Opioid-Minimizing Pain Management Platforms
Leading medical societies recommend opioid-minimizing pain management strategies to enhance recovery after obstetric and gynecologic procedures
ACOG
A stepwise, multimodal pain management strategy, including local anesthetics delivered by wound infiltration or TAP block, is recommended to control pain and minimize opioid administration
Postoperative minimization of opioid use reduces nausea and vomiting, impairment of bowel function, delayed mobilization, and pulmonary morbidity9
ACOG, American College of Obstetrics and Gynecologists; TAP, transversus abdominis plane.
SOAP
Multimodal analgesia, including wound infiltration or regional blocks (eg, TAP block), should be used to reduce pain, improve mobilization, reduce opioid use in the hospital after discharge, and decrease opioid side effects4
SOAP, Society for Obstetric Anesthesia and Perinatology; TAP, transversus abdominis plane.
SGO
Advocate for the goal of reducing opioid misuse, and optimizing availability and use of non-opioid methods of pain control10
SGO, Society of Gynecologic Oncology.
ERAS
Avoiding opioid use within a multimodal postoperative analgesia pathway, with greater emphasis on non-opioid medications such as liposomal bupivacaine can improve patient experience and functional recovery after surgery5
ERAS, enhanced recovery after surgery.
Related Resources
