What patients fear most is pain

70%of patients

are prescribed opioids for postsurgical pain after a third molar extraction.2

They also fear opioids because of the related risks


of future opioid use in patients prescribed opioids legitimately in 12th grade.3

With EXPAREL, you can make patients comfortable with less reliance on opioids

Non-opioid EXPAREL is a proven, long-lasting anesthetic that controls pain for the first few days after surgery—when your patients need relief most.

In third molar extraction, dental implants, and orthognathic and craniofacial procedures, opioid-sparing EXPAREL consistently demonstrates4-7:

less need

Third Molar Extraction4‡

  • 59% REDUCTION in total prescribed opioids in MMEs4; 47.1 vs 113.8 MMEs; rate ratio, 0.41 (0.39–0.44); P <0.0001
  • 57% REDUCTION in opioid prescription refill rate; 3.3% vs 7.7%, P=0.028
less pain

Craniofacial Procedures

  • 97% REDUCTION in pain scores in the first 4 hours of the postsurgical period 0.1 ± 0.5 (SD) vs 3.7 ± 3.5 (SD); P <0.001
  • SIGNIFICANT REDUCTION in pain scores in the first 24 hours of the postsurgical period; 12 (P=0.010), 16 (P=0.002), 20 (P=0.006), and 24 (P=0.009) hours

The AAOMS supports the use of opioid-minimizing pain management strategies

“The oral and maxillofacial surgeon should avoid starting treatment with long-acting or extended-release opioid analgesics.”8


Achieve optimal results with proper administration volume and technique

The videos below include a variety of OMFS procedures that demonstrate how to administer EXPAREL for optimal pain control and coverage.

Third Molar Extraction (Surgical Site Infiltration) Performed by: Dr Gill

For more information on EXPAREL, connect with us here

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This video represents an individual clinician experience with and methodology for using EXPAREL.

Pacira BioSciences, Inc., recognizes that there are other methodologies for administering local anesthetics, as well as individual patient considerations when selecting the dose for a specific procedure.

Please see Important Safety Information below and refer to the Full Prescribing Information.

More Videos

Third Molar Extraction (Surgical Site Infiltration) Performed by: Dr Gill

Temporomandibular Joint Arthroplasty (Surgical Site Infiltration) Performed by: Dr Bouloux

Full Maxillary Reconstruction (Surgical Site Infiltration) Performed by: Dr Quereshy

Third Molar Extraction Infiltration Technique Animation

Get answers to frequently asked questions in oral surgery

Spread awareness about your non-opioid approach for managing postsurgical pain with patients and the community

AAOMS=American Association of Oral and Maxillofacial Surgeons; MME=morphine milligram equivalent; OMFS=oral and maxillofacial surgery; SD=standard deviation; TMJ=temporomandibular joint.

*According to a 2018 global survey by DentaVox.

†The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

Results from a retrospective cross-sectional analysis of patients undergoing third molar extraction (N=600) receiving local infiltration with EXPAREL (n=300) compared with patients who did not receive EXPAREL (n=300).

§Results from a retrospective cohort study of patients undergoing alveolar bone grafting with an open iliac crest bone harvest (N=38) receiving EXPAREL at the hip donor site (n=17) compared with patients receiving bupivacaine HCl at the hip donor site (n=21).

ASP, average sales price; CMS, Centers for Medicare and Medicaid Services.

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1 out of 3 Americans avoids the dentist due to dental fear.<sup>1*</sup>