Administration volume and technique are critical to achieving optimal results

The videos below include a variety of surgical procedures that demonstrate examples of how to administer EXPAREL for optimal pain control and coverage.

Arthroscopic Rotator Cuff RepairPerformed by: Dr Sethi

For more information on EXPAREL, connect with us here

play button white

This video represents an individual clinician experience with and methodology for using EXPAREL.

Pacira BioSciences, Inc., recognizes that there are other methodologies for administering local anesthetics, as well as individual patient considerations, when selecting the dose for a specific procedure.

Please see Important Safety Information below and refer to the Full Prescribing Information.

More Videos

Arthroscopic Rotator Cuff Repair Performed by: Dr Sethi

Interscalene Brachial Plexus Nerve Block in Rotator Cuff Repair Performed by: Dr Hutchins

Reverse Total Shoulder Arthroplasty Performed by: Dr Routman

Multimodal protocol and results: shoulder arthroplasty

Study design1

Retrospective study comparing the efficacy of EXPAREL and dexamethasone intraoperatively as part of multimodal pain management (n=31) versus standard multimodal pain management (n=24) in patients undergoing elective shoulder arthroplasty.

Multimodal protocol


  • Single-injection interscalene block
    • Acetaminophen 1000 mg intravenously
    • Gabapentin 600 mg orally
    • Oxycodone 10 mg orally
    • Celecoxib 200 mg orally


  • Standard multimodal group: none
  • EXPAREL group:
    • EXPAREL 266 mg/20 mL + saline 20 mL + 0.25% bupivacaine HCl with epinephrine 10 mL*
    • Dexamethasone 8 to 10 mg intravenously


  • Ketorolac intravenously
  • Acetaminophen intravenously
  • Gabapentin orally
  • Oxycodone 5 mg and 10 mg orally for mild to moderate pain
  • Hydromorphone 0.5 mg, 1 mg, and 2 mg intravenously for moderate to severe pain

Patients who received multimodal analgesia with EXPAREL

Lower pain level
  • 3.5 vs 7.5 VAS pain score on POD 1 (P<0.001)
Fewer opioids used in PACU*†
  • 20 mg vs 40.5 mg in cumulative utilization (P<0.001)
Shorter LOS
  • 1 day vs 2 days (P<0.001)

*The use of EXPAREL in combination with epinephrine is not part of the approved label.

Opioid intake measured in MED (mg).

LOS, length of stay; MED, morphine equivalent dosing; POD, postoperative day; VAS, visual analog scale; ISBP, interscalene brachial plexus.